Download e-book for iPad: ABC Transporters and Multidrug Resistance (Wiley Series in by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

ISBN-10: 0470227346

ISBN-13: 9780470227343

A complete assessment of the most up-tp-date medical learn on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are identified to play a vital position within the improvement of multidrug resistance (MDR). MDR is the facility of pathologic cells, reminiscent of tumors, to resist chemical compounds designed to focus on and damage such cells. In MDR, sufferers who're on medicine finally increase resistance not to merely the drug they're taking, yet to numerous types of drugs.ABC Transporters and Multidrug Resistance bargains a vital source for pharmaceutical researchers who're operating to find medicines to counteract multidrug resistance in ailments akin to melanoma. in a single complete quantity, this e-book features a selection of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.This entire quantity offers an summary at the description of the constitution, the genome, general tissue expression, physiological point, and mechanism of motion of the ABC protein. The specialist individuals discover the expression, detection, and implications of ABC proteins in hematological malignancies and good tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. furthermore, the e-book bargains crucial info at the organic and medical point of multidrug resistance.

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Extra resources for ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)

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2007. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446: 749–757. 6. Juliano RL and Ling V. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152–162. 7. Gottesman MM and Ling V. 2006. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research. FEBS Lett 580: 998–1009. 8. Loo TW and Clarke DM. 2005. Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

The majority of experimental data strongly supports this drug-pump model (137). Drugs interact in cytoplasm with the transmembrane region of the two halves of P-gp (transmembrane segments 5–6 and 11–12), coming together to form a single, large, and flexible drug-binding pocket, possibly containing several binding sites for the substrate (8). It seems that at least two molecules can simultaneously bind different overlapping regions. Then, P-gp expels the drugs directly into the extracellular medium due to the energy from ATP hydrolysis.

J Histochem Cytochem 54: 1159–1167. 97. Ha SN, Hochman J, and Sheridan RP. 2007. Mini review on molecular modeling of P-glycoprotein (Pgp). Curr Top Med Chem 7: 1525–1529. 98. Borst P and Elferink RO. 2002. Mammalian ABC transporters in health and disease. Annu Rev Biochem 71: 537–592. 99. Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E et al. 2005. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development) by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert


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